Endocrine Abstracts

Aims: Endogenous and exogenous oestrogens have previously been shown to improve postprandial lipid metabolism, probably due to up-regulation of hepatic LDL receptors. We used stable isotope techniques to investigate the contribution of muscle oxidation of dietary lipid to this improvement.Methods: Matched groups of healthy premenopausal (n=8) and postmenopausal (n=8) women and postmenopausal women taking oestrogen replacement therapy (HRT;...

Background: Postprandial hypertriglyceridaemia is an independent risk factor for cardiovascular diseases. An acute rise of insulin in the fed state suppresses hormone-sensitive lipase to inhibit free fatty acids (FFAs) mobilisation from adipose tissue, and up-regulates lipoprotein lipase to increase FFAs influx to adipose tissue from chylomicrons, that is blunted in insulin resistant states. Polycystic ovary syndrome (PCOS) is associated with insulin resistance and cardiovascu...